autoimmune diseases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7156	NIBR189		EBI2/GPR183
	NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively)		EBI2/GPR183
T9060	STM2457		Apoptosis , Others
	STM2457 is an inhibitor of the RNA methyltransferase METTL3 (IC50=16.9 nM) with selective and oral activity.STM2457 can be used in acute myeloid leukemia (AML) studies.		Apoptosis , Others
T38332	Complement factor D-IN-2		Complement System
	Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.		Complement System
T4316	ML365		Potassium Channel
	ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).		Potassium Channel
T22102	ML-178	CYM50179	Others
	ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM.		Others
T6761	Ossirene	AS101	IL Receptor , Caspase , Interleukin
	Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.		IL Receptor , Caspase , Interleukin
T7188	Piclidenoson	CF-101,IB-MECA	Apoptosis , Adenosine Receptor
	Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.		Apoptosis , Adenosine Receptor
T10549	Bisindolylmaleimide VIII acetate	Ro 31-7549 acetate,Bis VIII acetate	Apoptosis , PKC
	Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, resp...		Apoptosis , PKC
T78607	JAK-STAT-IN-1		JAK , STAT
	JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.		JAK , STAT
T26636	Antifolate C2	AGF 154,AGF154,AGF-154	Others
	Antifolate C2 (AGF 154) has antitumor activity with an IC of 0.14 nM measured in a growth inhibition assay of human tumor cells.Antifolate C2 can be used for the study of cancer and autoimmune diseases.		Others
T39654	Afimetoran	BMS-986256	TLR
	Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.		TLR
T30077L	Anisperimus HCl	LF 150195 HCl,Anisperimus HCl（170368-04-4 Free base）	Others
	Anisperimus HCl (LF 150195 HCl) is a small molecule immunizing agent for the study of autoimmune diseases.		Others
T60145	CCR6 antagonist 1		CCR
	CCR6 antagonist 1, a chemical compound acting as a CCR6 antagonist, effectively inhibits the CCL20/CCR6 axis. Its utility lies in research focused on autoimmune-mediated inflammatory diseases, including inflammatory bowe...		CCR
T12753	RORγt Inverse agonist 6		ROR
	RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.		ROR
T6749	A-1331852		BCL
	A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.		BCL
T62858	HGPR91 antagonist 3		GPR
	hGPR91 antagonist 3 is an orally active, potent, and selective hGPR91 antagonist. hGPR91 antagonist 3 is used to study hypertension, autoimmune diseases, and retinal angiogenesis. hGPR91 antagonist 3 has been shown to be...		GPR
T15096	Delgocitinib	JTE-052,Corectim（Delgocitinib）	Tyrosine Kinases , JAK
	Delgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune d...		Tyrosine Kinases , JAK
T60542	BTK-IN-16		BTK
	BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.		BTK
TQ0295	Coumestrol		Estrogen Receptor/ERR
	Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.		Estrogen Receptor/ERR
T60060	ACSS2-IN-2	MTB-9655	Fatty Acid Synthase
	ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several dis...		Fatty Acid Synthase